Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination
نویسندگان
چکیده
منابع مشابه
Retinoid X receptor activation reverses age-related deficiencies in myelin debris phagocytosis and remyelination.
The efficiency of central nervous system remyelination declines with age. This is in part due to an age-associated decline in the phagocytic removal of myelin debris, which contains inhibitors of oligodendrocyte progenitor cell differentiation. In this study, we show that expression of genes involved in the retinoid X receptor pathway are decreased with ageing in both myelin-phagocytosing human...
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ژورنال
عنوان ژورنال: Brain
سال: 2015
ISSN: 0006-8950,1460-2156
DOI: 10.1093/brain/awv289